Antibiotic Research UK’s research programmes are overseen by the Science Committee consisting of:
Professor Colin Garner
PhD DSc FRCPath (Chief Executive)
Professor Chris G Dowson
Dr. Lloyd Czaplewski
Chief Scientific Officer, Persica Pharmaceuticals
Lloyd has over 23-years of R&D experience in biological and chemical entities across multiple therapeutic areas at technical, managerial and corporate levels. For the last 15-years Lloyd has focused on antibacterial R&D, especially DNA supercoiling and bacterial cell wall biosynthesis. Career highlights include a demonstrated ability to create and lead structure-informed screening, hit & lead optimization programmes leading to compounds with class leading in vivo efficacy.
Lloyd is a prolific inventor with a strong patent (26) and publication (34) record. He has created, managed and buillt Venture Capital funded businesses. Lloyd has a strong record of fund raising (£>23m) from UK, Europe, USA and Japan including charities (Wellcome Trust), Government (DTI, UK & NIAID, USA), Corporate (Astellas), VC investment groups and business angels. He is currently Chief Scientific Officer of Persica Pharmaceuticals.
Professor Chris Schofield
Professor and Head of Organic Chemistry, University of Oxford
Professor Christopher Schofield, FRS is Professor and Head of Organic Chemistry at the University of Oxford, and has world class expertise in the chemical biology of the hypoxic response in humans and other animals with breakthrough work in the field including the identification of the hypoxia inducing factor/hydroxylases and the JmjC prolyl family of oxygenases. He has published >200 relevant papers (including in ACIE, JACS, Cell, Nature, Nat. Chem., Nat. Commun., PNAS, Science, Science Transl. Med.; >20000 citations; h-index >65). His group is highly collaborative and has been involved in multiple major research initiatives, including the EPSRC Synthesis for Biology and Medicine CDT, Oxford Center for Molecular Science, the Target Discovery Initiate, and others; he has career income for his group’s research of >£15m. Chris and his group are particularly interested in metallo-proteases and the variety of unusual enzymes involved in antibiotic biosynthesis; the carbapenems and clavam families of β-lactams are of particular interest.
Professor Mark Moloney
Professor of Organic Chemistry, University of Oxford
Professor Mark Moloney is currently Professor of Chemistry, having previously been Reader in Chemistry; he completed his undergraduate (B.Sc.(Hons.) and University Medal) and graduate studies (Ph.D. (Chemistry)) at the University of Sydney, Australia. On arriving in the UK he embarked on research related to penicillin biosynthesis in the research group of Professor Sir Jack Baldwin FRS, where he worked on photoaffinity labelling studies of IPNS using an approach with diazirine-modified tripeptides to probe the enzyme binding site. Mark is currently working on the development of novel antibiotics through the synthesis of hybridised compounds in the hope of tackling antibacterial resistance.
Professor Alasdair MacGowan
Professor of Antimicrobial Therapeutics, University of Bristol
Professor Alasdair MacGowan, serves as Professor of Clinical Microbiology & Antimicrobial Therapeutics at the University of Bristol, and Consultant Medical Microbiologist and Head of Research & Specialist Services in the Department of Medical Microbiology at North Bristol NHS Trust. Professor MacGowan has been a member of Infectious Disease Clinical Advisory Board of PolyMedix, Inc. since November 2010. Alisdair’s main research interests are in antibiotic resistance epidemiology in the community, and antibacterial pharmacokinetics/pharmacodynamics.
Professor David Roper
Professor in Microbiology, Warwick University
David Roper is a former MRC career Development fellow at the University of York and now reader in Structural Biology at the University Warwick. The Roper group uses structural biology techniques, principally X-ray structural determination, in combination with molecular biology and biochemical approaches, to investigate the molecular basis of microbial physiology in relation to antibiotic resistance and bacterial cell wall (peptidoglycan) biosynthesis in Gram-positive and Gram-negative pathogens. In addition his research group also uses a synthetic and translational biology approaches to obtain and reengineer pathway intermediates as chemical probes, substrates and inhibitors. This approach not only allows novel insight to the biology underpinning these pathways but also enables biotechnological exploration and exploitation. He was recently awarded a Personal Chair by the University of Warwick for his outstanding research contributions.
Dr Tim Tasker
Chief Medical Officer, Heptares Pharmaceuticals
Tim is a medical graduate from the University of Oxford and has had global roles within large Pharma & Biotech including SmithKlineBeecham, Evotec and most recently Heptares. He is and R&D specialist with Cross Therapeutic area experience across all phases of drug development and has conducted clinical studies in US/UK/Europe/Australia. He has experience of drug regulators in the UK, Europe, the USA and Australia to gain programme approval for clinical studies across all zones. He has led global teams to deliver in both big pharma internal.
Dr David Wareham
Clinical Senior Lecturer / Honorary Consultant in Microbiology, Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry
David Wareham qualified (MBBS) from the London Hospital Medical College in 1994 and trained in general medicine before specialist training in Medical Microbiology (FRCPath). He was awarded a Clinical Training Fellowship to study aspects of Pseudomonas aeruginosa pathogenicity at Queen Mary University in 2002 and appointed as Senior Clinical Lecturer in Microbiology in July 2005 (PhD). He is an Honorary Consultant Microbiologist at Barts Health NHS Trust responsible for aspects of intensive care microbiology. He heads the Antimicrobial Research Group which is involved in characterizing the mechanisms underlying the development and persistence of antimicrobial resistance as well as the consequences this may have on the organism and its capacity to cause human disease. This combines genomics, molecular biology, in-vitro and in-vivo (invertebrates) studies, epidemiological and clinical data in an attempt to dissect the complex relationship between host, pathogen and resistance. Research is driven by problems encountered in daily clinical practice and in recent years has focused on multi-drug resistant Gram-negative bacteria such as Acinetobacter baumannii, Stenotrophomonas maltophilia and carbapenem resistant Enterobacteria. Areas of particular interest include the identification of novel resistance determinants, evaluation of novel antimicrobial treatments, pharmacodynamic and pharmacokinetic analysis of new and repurposed combination therapies, virulence studies of emerging pathogens and interventions to prevent the spread of resistant organisms in the hospital environment.
Professor Neil Woodford
Head, AMRHAI (Public Health England), Visiting Professor, Department of Medicine, Imperial College
Prof Neil Woodford is the Public Health England (PHE) Lead for the Applied Molecular Bacteriology theme of the National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance. Professor Woodford directs the research in theme with Professor Shiranee Sriskandan, the Imperial College Lead.
The HPRU, which was established on 01 April 2014, is a partnership between Imperial College London, Public Health England, Cambridge University Veterinary School, the Wellcome Trust Sanger Institute and Imperial College Health Partners North West London Academic Health Science Network. The Unit was funded along with 12 others, in priority areas from immunisation to radiation hazards, to bring Universities to work in partnership with Public Health England to support excellent health protection research relevant to the needs of Public Health England.
Professor Woodford is also the Head of the Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit at Public Health England. He is an international expert in molecular detection of the genetic determinants of key resistances through AMRHAI.
He has worked on antibiotic resistance for over 25 years, and has co-authored more than 250 publications, edited three books on the subject and is a Fellow of the Royal College of Pathologists on the basis of his published works. He served for 10 years as an Editor of the Journal of Antimicrobial Chemotherapy, and is on the Editorial Board of Microbial Drug Resistance.