Antibiotic Research UK’s research programmes are overseen by the Science Committee consisting of:
Professor Colin Garner
PhD DSc FRCPath (Chief Executive)
Professor Chris G Dowson
Dr. Lloyd Czaplewski
Chief Scientific Officer, Persica Pharmaceuticals
Lloyd has over 23-years of R&D experience in biological and chemical entities across multiple therapeutic areas at technical, managerial and corporate levels. For the last 15-years Lloyd has focused on antibacterial R&D, especially DNA supercoiling and bacterial cell wall biosynthesis. Career highlights include a demonstrated ability to create and lead structure-informed screening, hit & lead optimization programmes leading to compounds with class leading in vivo efficacy.
Lloyd is a prolific inventor with a strong patent (26) and publication (34) record. He has created, managed and buillt Venture Capital funded businesses. Lloyd has a strong record of fund raising (£>23m) from UK, Europe, USA and Japan including charities (Wellcome Trust), Government (DTI, UK & NIAID, USA), Corporate (Astellas), VC investment groups and business angels. He is currently Chief Scientific Officer of Persica Pharmaceuticals.
Professor Chris Schofield
Professor and Head of Organic Chemistry, University of Oxford
Professor Christopher Schofield, FRS is Professor and Head of Organic Chemistry at the University of Oxford, and has world class expertise in the chemical biology of the hypoxic response in humans and other animals with breakthrough work in the field including the identification of the hypoxia inducing factor/hydroxylases and the JmjC prolyl family of oxygenases. He has published >200 relevant papers (including in ACIE, JACS, Cell, Nature, Nat. Chem., Nat. Commun., PNAS, Science, Science Transl. Med.; >20000 citations; h-index >65). His group is highly collaborative and has been involved in multiple major research initiatives, including the EPSRC Synthesis for Biology and Medicine CDT, Oxford Center for Molecular Science, the Target Discovery Initiate, and others; he has career income for his group’s research of >£15m. Chris and his group are particularly interested in metallo-proteases and the variety of unusual enzymes involved in antibiotic biosynthesis; the carbapenems and clavam families of β-lactams are of particular interest.
Professor Mark Moloney
Professor of Organic Chemistry, University of Oxford
Professor Mark Moloney is currently Professor of Chemistry, having previously been Reader in Chemistry; he completed his undergraduate (B.Sc.(Hons.) and University Medal) and graduate studies (Ph.D. (Chemistry)) at the University of Sydney, Australia. On arriving in the UK he embarked on research related to penicillin biosynthesis in the research group of Professor Sir Jack Baldwin FRS, where he worked on photoaffinity labelling studies of IPNS using an approach with diazirine-modified tripeptides to probe the enzyme binding site. Mark is currently working on the development of novel antibiotics through the synthesis of hybridised compounds in the hope of tackling antibacterial resistance.
Professor Alasdair MacGowan
Professor of Antimicrobial Therapeutics, University of Bristol
Professor Alasdair MacGowan, serves as Professor of Clinical Microbiology & Antimicrobial Therapeutics at the University of Bristol, and Consultant Medical Microbiologist and Head of Research & Specialist Services in the Department of Medical Microbiology at North Bristol NHS Trust. Professor MacGowan has been a member of Infectious Disease Clinical Advisory Board of PolyMedix, Inc. since November 2010. Alisdair’s main research interests are in antibiotic resistance epidemiology in the community, and antibacterial pharmacokinetics/pharmacodynamics.
Professor David Roper
Professor in Microbiology, Warwick University
David Roper is a former MRC career Development fellow at the University of York and now reader in Structural Biology at the University Warwick. The Roper group uses structural biology techniques, principally X-ray structural determination, in combination with molecular biology and biochemical approaches, to investigate the molecular basis of microbial physiology in relation to antibiotic resistance and bacterial cell wall (peptidoglycan) biosynthesis in Gram-positive and Gram-negative pathogens. In addition his research group also uses a synthetic and translational biology approaches to obtain and reengineer pathway intermediates as chemical probes, substrates and inhibitors. This approach not only allows novel insight to the biology underpinning these pathways but also enables biotechnological exploration and exploitation. He was recently awarded a Personal Chair by the University of Warwick for his outstanding research contributions.
Dr David Wareham
Clinical Senior Lecturer / Honorary Consultant in Microbiology, Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry
David Wareham qualified (MBBS) from the London Hospital Medical College in 1994 and trained in general medicine before specialist training in Medical Microbiology (FRCPath). He was awarded a Clinical Training Fellowship to study aspects of Pseudomonas aeruginosa pathogenicity at Queen Mary University in 2002 and appointed as Senior Clinical Lecturer in Microbiology in July 2005 (PhD). He is an Honorary Consultant Microbiologist at Barts Health NHS Trust responsible for aspects of intensive care microbiology. He heads the Antimicrobial Research Group which is involved in characterizing the mechanisms underlying the development and persistence of antimicrobial resistance as well as the consequences this may have on the organism and its capacity to cause human disease. This combines genomics, molecular biology, in-vitro and in-vivo (invertebrates) studies, epidemiological and clinical data in an attempt to dissect the complex relationship between host, pathogen and resistance. Research is driven by problems encountered in daily clinical practice and in recent years has focused on multi-drug resistant Gram-negative bacteria such as Acinetobacter baumannii, Stenotrophomonas maltophilia and carbapenem resistant Enterobacteria. Areas of particular interest include the identification of novel resistance determinants, evaluation of novel antimicrobial treatments, pharmacodynamic and pharmacokinetic analysis of new and repurposed combination therapies, virulence studies of emerging pathogens and interventions to prevent the spread of resistant organisms in the hospital environment.
Dr Chris Longshaw
EU Scientific Advisor, Infectious Diseases, Shionogi Limited, UK
Chris is a Medical Scientific Affairs Specialist with extensive European pharmaceutical industry experience in the field of Antimicrobial Chemotherapy and Infectious Disease. He has worked in both Pharmaceutical and Crop Protection sectors, with roles spanning the full product life cycle from early phase Antimicrobial discovery and lead development, through regulatory submissions to post-market commercialization and Medical/Scientific Affairs. Currently Chris is EU Scientific Advisor, Infectious Diseases for Shionogi Pharmaceuticals and works successfully with medical, commercial and development teams at National, European and Global levels to provide medical and scientific leadership. He has also experience of coordinating microbiology research programmes ranging from large, multi-national epidemiology and resistance surveillance studies to more focused in vitro/in vivo pharmacodynamic studies supporting brand strategy and life cycle management. Chris is a graduate of the University of Leeds where he also obtained his PhD.